Cayenne (Capsicum annuum) It has been used by cultures for over 9000 years. The Capsicum family includes bell peppers, red peppers, paprika, and pimento, but the most famous spicy members of the family are cayenne. The main active constituent in cayenne is capsaicin. Disclaimer: These statements have not been evaluated by the FDA and are not intended to diagnose, cure, treat or prevent disease. Individual results may vary, and before using any supplements, it is always advisable to consult with your own health care provider.